Ivlieva N Yu, Timofeeva N O
Department of Higher Nervous Activity, M. V. Lomonosov Moscow State University, Vorob'evy Gory, 119899 Moscow, Russia.
Neurosci Behav Physiol. 2003 Nov;33(9):919-28. doi: 10.1023/a:1025909124462.
The activity of 91 neurons in the compact and diffuse zones of the pedunculopontine nucleus of freely mobile rabbits was studied during performance of a food-related operant conditioned reflex. A total of 37.4% of the neurons recorded showed reactivity to the conditioned stimulus, which is evidence that the pedunculopontine nucleus is involved in operant learning. A significant predominance of excitatory responses to the conditioned stimulus and to food reinforcement was demonstrated. The main patterns of cell responses were identified, these reflecting the nature of the effect of the conditioned stimulus on neuron activity, the structure of the behavioral act, and the properties of the reinforcement, and demonstrating a relationship between the pedunculopontine nucleus and the processes of attention, motor learning, and reinforcement. Differences were seen in the associative reactive properties of the compact and diffuse zones of the pedunculopontine nucleus to the conditioned stimulus and reinforcement, which is evidence for the functional diversity of this formation and suggests a leading role for the cholinergic compact zone in food-related operant learning and reinforcement, the diffuse zone having a leading role in food-related classical conditioned-reflex learning.
在自由活动的家兔进行与食物相关的操作性条件反射过程中，对其脚桥核致密部和弥散部的91个神经元的活动进行了研究。所记录的神经元中，共有37.4%对条件刺激表现出反应性，这证明脚桥核参与了操作性学习。对条件刺激和食物强化的兴奋性反应占显著优势。确定了细胞反应的主要模式，这些模式反映了条件刺激对神经元活动的影响性质、行为动作的结构以及强化的特性，并表明脚桥核与注意力、运动学习和强化过程之间存在关联。在脚桥核致密部和弥散部对条件刺激和强化的联合反应特性方面存在差异，这证明了该结构的功能多样性，并表明胆碱能致密部在与食物相关的操作性学习和强化中起主导作用，而弥散部在与食物相关的经典条件反射学习中起主导作用。
