Leri F, Franklin K B
Department of Psychology, McGill University, 1205 Dr. Penfield Ave., Montreal, Quebec H3A-1B1, Canada.
Brain Res. 1998 Oct 5;807(1-2):187-92. doi: 10.1016/s0006-8993(98)00762-8.
Bilateral N-methyl-d-aspartate lesions of the pedunculopontine tegmental nucleus (PPTg) blocked the acquisition of a delayed non-matching to position task (DNMP) performed in a T-maze. This acquisition impairment, however, was reversed by pre-testing injections of diazepam (1 mg/kg). These results, in addition to the finding that PPTg lesions elevated anxiety as measured by the elevated plus maze, suggest that PPTg is not involved in learning or memory, but in the regulation of anxiety.
脚桥被盖核（PPTg）的双侧N-甲基-D-天冬氨酸损伤阻断了在T迷宫中进行的延迟位置不匹配任务（DNMP）的习得。然而，这种习得障碍可通过预先测试注射地西泮（1毫克/千克）而逆转。这些结果，再加上通过高架十字迷宫测量发现PPTg损伤会加剧焦虑，表明PPTg不参与学习或记忆，而是参与焦虑调节。
