Kerr M Kathleen
Department of Biostatistics, University of Washington, Box 357232, Seattle, Washington, USA.
Biometrics. 2003 Dec;59(4):822-8. doi: 10.1111/j.0006-341x.2003.00096.x.
This article describes the theoretical and practical issues in experimental design for gene expression microarrays. Specifically, this article 1) discusses the basic principles of design (randomization, replication, and blocking) as they pertain to microarrays, and 2) provides some general guidelines for statisticians designing microarray studies.
本文描述了基因表达微阵列实验设计中的理论和实际问题。具体而言,本文1)讨论了与微阵列相关的设计基本原则(随机化、重复和区组化),以及2)为设计微阵列研究的统计学家提供了一些通用指南。