Verhoeven Carole H J, Dieben Th O M
Clinical Development Department, Contraception, NV Organon, P.O. Box 20, 5340 BH Oss, The Netherlands.
Contraception. 2004 Mar;69(3):197-9. doi: 10.1016/j.contraception.2003.10.014.
We investigated the effect of tampon co-usage on systemic exposure to etonogestrel (ENG) and ethinylestradiol (EE) from the combined contraceptive vaginal ring, NuvaRing. One cycle of ring use consists of 3 weeks of ring use followed by a 1-week ring-free period. Fourteen healthy women were randomized to use both NuvaRing and tampons (Kotex( regular) or NuvaRing alone for one cycle; participants then switched to the alternate treatment regimen for a second cycle of ring use. The first tampon was self-administered on day 8 of the interaction cycle; 4 tampons a day were used for 3 consecutive days. Tampon co-usage did not result in any changes in serum ENG or EE concentrations and is thus not expected to compromise the ring's contraceptive efficacy.
我们研究了同时使用卫生棉条对复方避孕阴道环NuvaRing中依托孕烯（ENG）和炔雌醇（EE）全身暴露的影响。一个环使用周期包括3周的环使用期，随后是1周的无环期。14名健康女性被随机分为同时使用NuvaRing和卫生棉条（高洁丝常规型）或仅使用NuvaRing一个周期；参与者随后切换到交替治疗方案进行第二个环使用周期。在交互周期的第8天自行使用第一根卫生棉条；连续3天每天使用4根卫生棉条。同时使用卫生棉条不会导致血清ENG或EE浓度发生任何变化，因此预计不会损害环的避孕效果。
