Hagley M T, Murphy D P, Mullins D, Zarconi J
Department of Medicine, Akron City Hospital, OH 44309.
Am J Kidney Dis. 1992 Aug;20(2):177-9. doi: 10.1016/s0272-6386(12)80547-6.
Glomerulomegaly is associated with congenital cyanotic heart disease and has heretofore been considered a benign condition. We describe a patient with congenital cyanotic heart disease and glomerulomegaly. Deterioration of renal function was demonstrated by comparison of creatinine clearances measured at the time of kidney biopsy and 4 years later. No alteration in kidney histology other than glomerulomegaly and focal glomerulosclerosis at autopsy could account for this deterioration. This is the first description of deterioration of renal function in a patient with glomerulomegaly and congenital cyanotic heart disease. This observation may influence the management of patients with glomerulomegaly and congenital cyanotic heart disease who are potential recipients of heart or heart-lung allografts.
肾小球肿大与先天性青紫型心脏病相关，迄今为止一直被认为是一种良性病症。我们描述了一名患有先天性青紫型心脏病和肾小球肿大的患者。通过比较肾活检时及4年后测得的肌酐清除率，证实肾功能恶化。尸检时除了肾小球肿大和局灶性肾小球硬化外，肾脏组织学无其他改变，无法解释这种恶化。这是首次对患有肾小球肿大和先天性青紫型心脏病患者肾功能恶化的描述。这一观察结果可能会影响对可能接受心脏或心肺同种异体移植的肾小球肿大和先天性青紫型心脏病患者的管理。
