Gibb G M, de Silva R, Revesz T, Lees A J, Anderton B H, Hanger D P
Department of Neuroscience, Box PO 38, Institute of Psychiatry KCL, De Crespigny Park, London SE5 8AF, UK.
Brain Res Mol Brain Res. 2004 Feb 5;121(1-2):95-101. doi: 10.1016/j.molbrainres.2003.11.007.
We found previously that aggregated insoluble tau protein in progressive supranuclear palsy (PSP) brains exhibits a heterogeneous pattern that is not segregated by the type of clinical presentation. Here we have investigated tau isoform composition from 20 PSP cases and found marked variation between different brains. Cases were classified into three groups, each comprising essentially of (1) 1N4R; (2) 1N4R and 1N3R; or (3) 1N4R, 1N3R and 0N4R tau isoforms. There was also an absence of a simple relationship between isoform composition and the pattern of insoluble tau before dephosphorylation. We conclude that there is distinct molecular heterogeneity in the involvement of tau isoforms in the tau pathology in PSP.
我们先前发现，进行性核上性麻痹（PSP）患者大脑中聚集的不溶性tau蛋白呈现出一种异质性模式，该模式不会因临床表现类型而有所区分。在此，我们研究了20例PSP患者的tau异构体组成，发现不同大脑之间存在显著差异。病例被分为三组，每组主要包括：（1）1N4R；（2）1N4R和1N3R；或（3）1N4R、1N3R和0N4R tau异构体。在去磷酸化之前，异构体组成与不溶性tau模式之间也不存在简单的关系。我们得出结论，在PSP的tau病理学中，tau异构体的参与存在明显的分子异质性。
