Douglas Joanne T
Division of Human Gene Therapy, Departments of Medicine, Pathology, and Surgery and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, AL, USA.
Methods Mol Biol. 2004;246:3-14. doi: 10.1385/1-59259-650-9:3.
Adenoviruses, which were first isolated in the 1950s, have been developed as gene-delivery vehicles, or vectors, since the early 1980s. The adenoviruses constitute the Adenoviridae family, which is divided into two genera: the Aviadenovirus genus infects only birds, whereas the Mastadenovirus genus contains viruses that infect a range of mammalian species. Human adenoviruses are classified into six subgroups based on the percentage of guanine and cytosine in the DNA molecules and the ability to agglutinate red blood cells. They are further subdivided into more than 50 serotypes, primarily on the basis of neutralization assays.
腺病毒于20世纪50年代首次被分离出来，自20世纪80年代初以来一直被开发用作基因传递载体或载体。腺病毒属于腺病毒科，该科分为两个属：禽腺病毒属仅感染鸟类，而哺乳动物腺病毒属包含感染一系列哺乳动物物种的病毒。人类腺病毒根据DNA分子中鸟嘌呤和胞嘧啶的百分比以及凝集红细胞的能力分为六个亚组。它们进一步细分为50多种血清型，主要基于中和试验。
