俄克拉荷马州绵羊中羊瘙痒病朊病毒蛋白基因（PRNP）的等位基因变体
Allelic variants of ovine prion protein gene (PRNP) in Oklahoma sheep.
作者信息
DeSilva U, Guo X, Kupfer D M, Fernando S C, Pillai A T V, Najar F Z, So S, Fitch G Q, Roe B A
机构信息
Department of Animal Science, Oklahoma State University, Stillwater, OK 74078, USA.
出版信息
Cytogenet Genome Res. 2003;102(1-4):89-94. doi: 10.1159/000075731.
1,144 sheep belonging to 21 breeds and known crosses were sequence analyzed for polymorphisms in the ovine PRNP gene. Genotype and allele frequencies of polymorphisms in PRNP known to confer resistance to scrapie, a fatal neurodegenerative disease of sheep, are reported. Known polymorphisms at codons 136 (A/V), 154 (H/R) and 171 (Q/R/H/K) were identified. The frequency of the 171R allele known to confer resistance to type C scrapie was 53.8% and the frequency of the 136A allele known to influence the resistance to type A scrapie was 96.01%. In addition, we report the identification of five new polymorphisms at codons 143 (H/R), 167 (R/S), 180 (H/Y), 195 (T/S) and 196 (T/S). We also report the identification of a novel allele (S/R) at codon 138.
对属于21个品种及已知杂交品种的1144只绵羊的绵羊朊蛋白（PRNP）基因多态性进行了序列分析。报告了已知赋予绵羊抗瘙痒病（一种绵羊致命性神经退行性疾病）能力的PRNP基因多态性的基因型和等位基因频率。鉴定出了密码子136（A/V）、154（H/R）和171（Q/R/H/K）处的已知多态性。已知赋予抗C型瘙痒病能力的171R等位基因频率为53.8%，已知影响抗A型瘙痒病能力的136A等位基因频率为96.01%。此外，我们报告了在密码子143（H/R）、167（R/S）、180（H/Y）、195（T/S）和196（T/S）处鉴定出五个新的多态性。我们还报告了在密码子138处鉴定出一个新的等位基因（S/R）。
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