Hillaby K, Aslam N, Salim R, Lawrence A, Raju K S, Jurkovic D
Early Pregnancy and Gynaecology Assessment Unit, King's College Hospital, London, UK.
Ultrasound Obstet Gynecol. 2004 Jan;23(1):63-7. doi: 10.1002/uog.946.
The aim of the study was to evaluate whether the presence of normal ovarian tissue adjacent to an adnexal tumor (the 'ovarian crescent sign') could assist in the preoperative differential diagnosis of adnexal lesions.
This was a prospective observational study including 100 women with a preoperative diagnosis of an adnexal mass. Demographic and biochemical data were collected and all women underwent a detailed transvaginal ultrasound scan. Tumor volume, morphological characteristics and Doppler features were recorded in each case. In addition, the tissue adjacent to the cyst was systematically examined for the presence of normal ovarian tissue. All the findings were compared to the final histological diagnosis.
Sixty-seven (67%) of the cysts removed were benign, nine (9%) were borderline and 24 (24%) women had invasive malignant lesions. Normal ovarian tissue was seen in 58/76 (76%) women with non-invasive lesions, and in one woman (4%) with an invasive malignancy. In the absence of normal ovarian tissue, ovarian cancer was diagnosed with a sensitivity of 96% and specificity of 76%.
The presence of normal ovarian tissue adjacent to an ovarian cyst is a useful morphological feature that may be used to help exclude an invasive ovarian malignancy in women with adnexal masses detected on ultrasound scan.
本研究旨在评估附件肿瘤旁正常卵巢组织的存在（“卵巢新月征”）是否有助于附件病变的术前鉴别诊断。
这是一项前瞻性观察性研究，纳入了100例术前诊断为附件包块的女性。收集人口统计学和生化数据，所有女性均接受详细的经阴道超声扫描。记录每例病例的肿瘤体积、形态特征和多普勒特征。此外，系统检查囊肿旁组织中正常卵巢组织的存在情况。将所有结果与最终组织学诊断进行比较。
切除的囊肿中67例（67%）为良性，9例（9%）为交界性，24例（24%）女性患有浸润性恶性病变。在58/76例（76%）非浸润性病变女性和1例（4%）浸润性恶性肿瘤女性中可见正常卵巢组织。在无正常卵巢组织的情况下，诊断卵巢癌的敏感性为96%，特异性为76%。
卵巢囊肿旁正常卵巢组织的存在是一个有用的形态学特征，可用于帮助排除超声检查发现附件包块的女性中的浸润性卵巢恶性肿瘤。
