Magdesian K G, Brook D, Wickler S J
Equine Research Center, California State Polytechnic University, Pomona 91768-4041.
Am J Vet Res. 1992 Jul;53(7):1149-53.
The temporal response of blood and serum proteins to chronic plasmapheresis was determined in 8 horses used in a commercial antibody enterprise. Plasmapheresis of between 4 and 11 L induced significant decreases in total protein, albumin, and IgG values. With the exception of a high hematocrit value for the first postplasmapheresis blood sample, there were no changes in erythrocyte or leukocyte measurements, and no changes in the proportions of serum protein in an electrophoretic profile. Regression equations generated for recovery of proteins after plasmapheresis indicated a return to preplasmapheresis values of total protein and albumin at approximately 1 month. Complications of repeated plasmapheresis were not detected when plasma extractions were done between 7 and 19 times at 30-day intervals.
在一家商业抗体企业使用的8匹马中，测定了血液和血清蛋白对慢性血浆置换的时间反应。4至11升的血浆置换导致总蛋白、白蛋白和IgG值显著降低。除血浆置换后首个血液样本的血细胞比容值较高外，红细胞或白细胞测量值无变化，电泳图谱中血清蛋白比例也无变化。血浆置换后蛋白质恢复的回归方程表明，总蛋白和白蛋白在约1个月时恢复到血浆置换前的值。当每隔30天进行7至19次血浆提取时，未检测到重复血浆置换的并发症。
