Mastropasqua Maria, Kanematsu Masayuki, Leonardou Polytimi, Braga Larissa, Woosley John T, Semelka Richard C
Department of Radiology, CB 7510, University of North Carolina, Chapel Hill, NC 27599-7510, USA.
Magn Reson Imaging. 2004 Jan;22(1):15-8. doi: 10.1016/j.mri.2003.02.001.
The purpose of our study was to assess the difference in magnetic resonance imaging (MRI) features of cavernous hemangiomas in patients with chronic liver disease compared them with hemangiomas in normal livers. We retrospectively searched our records of MRI of the liver between October 1998 and June 2002, and identified 76 hemangiomas in 49 patients (18 men and 31 women; age range 29-81 years [mean, 57 years]). Hemangiomas were classified into 3 groups: patients with cirrhosis [group 1, 8 lesions in 8 patients], patients with chronic hepatitis [group 2, 6 lesions in 5 patients], and patients without underlying liver disease [group 3, 62 lesions in 36 patients]. Four radiologists, blinded to clinical information, retrospectively reviewed in consensus the MRI findings of hemangiomas for number, size, signal intensities on T1- and T2-weighted images, and enhancement patterns on early- and late-phase postcontrast images. The mean lesion numbers and sizes were 1.0 and 16.2 +/- 9.6 mm, 1.2 and 15.3 +/- 7.1 mm, and 1.7 and 26.1 +/- 24.7 mm in groups 1-3, respectively. There was a correlation (p < 0.05, coefficient: 0.35) between lesion number and severity of liver disease. Although there was no significant difference in lesion size among the 3 groups, all of 11 lesions larger than 4 cm in diameter belonged to group 3. Almost all lesions appeared moderately hypointense on T1-weighted images and moderately hyperintense on T2-weighted images. Twenty-seven lesions showed immediate homogeneous enhancement (pattern 1), and 49 showed peripheral nodular enhancement with centripetal enhancement progression (pattern 2). There was no difference in frequency of enhancement patterns among the 3 groups. Hemangiomas were more often solitary in livers with chronic liver disease, large lesions were exclusively seen in livers without chronic liver disease, and there was a trend for small lesions in patients with chronic liver disease.
我们研究的目的是评估慢性肝病患者海绵状血管瘤的磁共振成像（MRI）特征与正常肝脏中血管瘤的差异。我们回顾性检索了1998年10月至2002年6月期间肝脏MRI记录，在49例患者（18例男性和31例女性；年龄范围29 - 81岁[平均57岁]）中识别出76个血管瘤。血管瘤分为3组：肝硬化患者[第1组，8例患者中的8个病灶]，慢性肝炎患者[第2组，5例患者中的6个病灶]，以及无潜在肝脏疾病的患者[第3组，36例患者中的62个病灶]。4名对临床信息不知情的放射科医生回顾性地共同评估了血管瘤的MRI表现，包括数量、大小、T1加权和T2加权图像上的信号强度以及对比剂注射后早期和晚期图像上的强化模式。第1 - 3组的平均病灶数量和大小分别为1.0和16.2±9.6mm、1.2和15.3±7.1mm、1.7和26.1±24.7mm。病灶数量与肝病严重程度之间存在相关性（p < 0.05，系数：0.35）。尽管3组之间病灶大小无显著差异，但直径大于4cm的11个病灶均属于第3组。几乎所有病灶在T1加权图像上呈中度低信号，在T2加权图像上呈中度高信号。27个病灶表现为立即均匀强化（模式1），49个病灶表现为周边结节状强化并向心性强化进展（模式2）。3组之间强化模式的频率无差异。慢性肝病肝脏中的血管瘤更常为单发，大病灶仅见于无慢性肝病的肝脏，慢性肝病患者中的病灶有变小的趋势。
