Thompson H J, Singh M
Center for Nutrition in the Prevention of Disease, AMC Cancer Research Center, Lakewood, Colorado 80214, USA.
J Mammary Gland Biol Neoplasia. 2000 Oct;5(4):409-20. doi: 10.1023/a:1009582012493.
While a number of agents have been shown to induce mammary carcinogenesis in the rat, premalignant stages of the disease have been best characterized in chemically-induced models, specifically those initiated by either 7,12 dimethylbenz[alpha]anthracene (DMBA) or 1-methyl-1-nitrosourea (MNU). In general, it appears that epithelial cells in mammary terminal end buds or terminal ductules are the targets of carcinogenic initiation, and that a series of morphologically identifiable steps are involved in the development of mammary carcinoma. The premalignant steps include ductal hyperplasia of the usual type and carcinoma in situ of the cribriform or comedo type; atypical ductal hyperplasia has not been reported. Thus the histogenesis of lesions occurring in chemically induced mammary carcinogenesis in the rat is similar to that observed in the human; although, the spectrum of lesions observed in the rat is limited. Opportunities to investigate the biological and molecular characteristics of premalignant breast disease in the rat are presented.
虽然已证明多种试剂可在大鼠中诱发乳腺癌，但该疾病的癌前阶段在化学诱导模型中得到了最好的表征，特别是那些由7,12-二甲基苯并[a]蒽（DMBA）或1-甲基-1-亚硝基脲（MNU）引发的模型。一般来说，乳腺终末芽或终末小导管中的上皮细胞似乎是致癌起始的靶点，并且乳腺癌的发展涉及一系列形态学上可识别的步骤。癌前步骤包括通常类型的导管增生和筛状或粉刺样原位癌；尚未报道非典型导管增生。因此，大鼠化学诱导性乳腺癌中发生的病变的组织发生与人类观察到的相似；尽管在大鼠中观察到的病变范围有限。这为研究大鼠癌前乳腺疾病的生物学和分子特征提供了机会。
