Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 3-5 Mănăștur Street, 400372 Cluj-Napoca, Romania.
Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 3-5 Mănăștur Street, 400372 Cluj-Napoca, Romania.
Oxid Med Cell Longev. 2020 Feb 26;2020:4014838. doi: 10.1155/2020/4014838. eCollection 2020.
Currently, one of the central problems in cancer management is the relapse of disease following conventional treatments, yet few therapeutic agents targeting resistance and tolerance exist. Propolis is known as a healing agent since ancient times. Therefore, over time, its curative properties have kept the interest of scientists, thus leading permanently to investigations of its other possible undiscovered effects. In this context, current experiments were performed to establish the chemopreventive potential of propolis extract (PE) (1.05 mg/kg BW/day) in N-methyl-N-nitrosourea- (MNU-) induced rat mammary tumors. MNU-inoculated/PE-treated rats had tumors of different physical attributes compared with control rats MNU-inoculated. The number of developed tumors (mean 49% versus 100%), incidence (mean 49% versus 100%), multiplicity (1.8 versus 3.7 ( < 0.001)), tumor volume (mean 10 cm versus 16 cm ( < 0.001)), and weight of the tumor mass (mean 7.42 g versus 9.00 g ( < 0.05)) were noted. The numbers of grade I tumors recorded for MNU-inoculated rats were 24 (Group 1) and 7 (Group 2) for MNU-induced/PE-treated rats. In the serum of rats MNU-inoculated/PE-treated were found higher levels of antioxidative enzymes (SOD, CAT, and GPx) than in MNU-induced. Taken together, these data indicate that propolis could be a chemopreventive agent against MNU-induced mammary carcinogenesis.
目前，癌症管理的核心问题之一是常规治疗后疾病的复发，但针对耐药性和耐受性的治疗药物很少。蜂胶自古以来就被认为是一种有治疗作用的物质。因此，随着时间的推移，它的治疗特性一直引起科学家的兴趣，从而导致对其其他可能未被发现的作用的不断研究。在这种情况下，目前进行了实验，以确定蜂胶提取物（PE）（1.05mg/kg BW/天）在 N-甲基-N-亚硝脲-（MNU）诱导的大鼠乳腺肿瘤中的化学预防潜力。与对照大鼠 MNU 接种相比，MNU 接种/PE 处理的大鼠的肿瘤具有不同的物理属性。发展中的肿瘤数量（平均值 49%对 100%）、发生率（平均值 49%对 100%）、多发性（1.8 对 3.7（<0.001））、肿瘤体积（平均值 10cm 对 16cm（<0.001））和肿瘤质量的重量（平均值 7.42g 对 9.00g（<0.05））都有所减少。MNU 接种大鼠的 I 级肿瘤数量为 24 个（第 1 组），MNU 诱导/PE 处理大鼠为 7 个（第 2 组）。在 MNU 接种/PE 处理大鼠的血清中发现抗氧化酶（SOD、CAT 和 GPx）的水平高于 MNU 诱导的大鼠。总之，这些数据表明蜂胶可能是一种预防 MNU 诱导的乳腺肿瘤发生的化学预防剂。
