Balbus-Kornfeld J M, Frumkin H
Pennsylvania Hospital, Philadelphia.
Arch Environ Health. 1992 Jul-Aug;47(4):285-91. doi: 10.1080/00039896.1992.9938363.
A urologist in Phoenixville, Pennsylvania, noted an apparent excess of invasive bladder cancer cases in his practice area during 1988 and 1989. Background incidence data for the local area were derived from state Cancer Registry statistics. Seventeen additional cases were noted during review of local hospital tumor registry data. Exposure evaluation included complete occupational histories for 15 index cases and correlation of residential histories with a review of local industries, water quality data, and toxic waste sites. The data were compared with incidence data from 1984 and 1985, and no increase in bladder cancer incidence for this area in 1988 and 1989 was evident. There was, however, a higher bladder cancer incidence among white males in the study area and Chester County, compared with Pennsylvania as a whole. Residential histories and environmental analysis did not reveal a common environmental carcinogen. A high incidence of occupational exposure to suspected bladder carcinogens was noted. In addition, all but 4 of the index cases smoked cigarettes. The study was limited by an extreme paucity of water supply analysis data. Effective environmental monitoring would promote more effective research into environmental carcinogenesis.
宾夕法尼亚州凤凰城的一位泌尿科医生注意到，1988年至1989年期间，他所在的执业区域侵袭性膀胱癌病例明显过多。当地的背景发病率数据来自该州癌症登记处的统计数据。在审查当地医院肿瘤登记数据时又发现了17例病例。暴露评估包括对15例索引病例的完整职业史，以及将居住史与当地工业、水质数据和有毒废物场地的审查结果进行关联分析。将这些数据与1984年和1985年的发病率数据进行比较，结果显示1988年和1989年该地区的膀胱癌发病率没有上升。然而，与宾夕法尼亚州整体情况相比，研究区域和切斯特县的白人男性膀胱癌发病率较高。居住史和环境分析未发现共同的环境致癌物。研究发现职业接触疑似膀胱致癌物的发生率很高。此外，除4例索引病例外，其余均吸烟。该研究因供水分析数据极度匮乏而受到限制。有效的环境监测将促进对环境致癌作用进行更有效的研究。
