Gross A R, Hoving J L, Haines T A, Goldsmith C H, Kay T, Aker P, Bronfort G
Cochrane Database Syst Rev. 2004(1):CD004249. doi: 10.1002/14651858.CD004249.pub2.
Neck disorders are common, disabling, and costly. The effectiveness of manipulation and mobilisation remains unclear.
To assess whether manipulation and mobilisation, either alone or in combination with other treatments, relieve pain or improve function/disability, patient satisfaction, and global perceived effect in adults with mechanical neck disorders (MND).
Computerised bibliographic databases including CENTRAL, MEDLINE, EMBASE, MANTIS, CINAHL, and ICL, were searched without language restrictions from their respective starting dates to March 2002.
The studies had to be randomised (RCT) or quasi-randomised and investigate the use of manipulation or mobilisation as a treatment for mechanical neck disorders.
Two independent reviewers conducted citation identification, study selection, data abstraction, and methodological quality assessment. Using a random effects model, relative risk and standardised mean differences were calculated. The reasonableness of combining studies was assessed on clinical and statistical grounds. In the absence of heterogeneity, pooled effect measures were calculated.
Of the 33 selected trials, 42% were high quality trials. Single sessions of manipulation or multiple sessions (3 to 11 weeks) of manipulation or mobilisation, or manipulation and mobilisation showed a nonsignificant benefit in pain relief when assessed against placebo, control groups or other treatments for acute/subacute/chronic MNDs with or without headache. There was strong evidence of benefit favouring multimodal care over a waiting list control for pain reduction [pooled SMD -0.85 (95% CI: -1.20 to -0.50)], improvement in function [pooled SMD -0.57 (95% CI: -0.94 to -0.21)] and global perceived effect [SMD -2.73 (95% CI: -3.30 to -2.16)] for subacute/chronic MND with or without headache. The common elements in this care strategy were mobilisation and/or manipulation plus exercise. There was moderate evidence of no difference in effect when multimodal care was compared to various other treatments.
REVIEWER'S CONCLUSIONS: Multimodal care has short-term and long-term maintained benefits for subacute/chronic MND with or without headache. The common elements in this care strategy were mobilisation and/or manipulation plus exercise. The evidence did not favour manipulation and/or mobilisation done alone or in combination with various other physical medicine agents; when compared to one another, neither was superior. There was insufficient evidence available to draw conclusions for neck disorder with radicular findings. The added benefit of exercise needs to be further explored. Factorial design would help determine the active treatment agent(s) within a treatment mix. Phase II trials would help identify the most effective treatment characteristics and dosages. Greater attention to methodological quality is needed.
颈部疾病常见、致残且代价高昂。手法治疗和松动术的有效性仍不明确。
评估手法治疗和松动术单独使用或与其他治疗方法联合使用时,能否缓解患有机械性颈部疾病(MND)的成年人的疼痛,改善其功能/残疾状况、患者满意度及整体感知效果。
检索了包括CENTRAL、MEDLINE、EMBASE、MANTIS、CINAHL和ICL在内的计算机化书目数据库,检索时间从各数据库起始日期至2002年3月,无语言限制。
研究必须为随机对照试验(RCT)或半随机试验,并调查手法治疗或松动术作为机械性颈部疾病治疗方法的使用情况。
两名独立的评审员进行文献识别、研究选择、数据提取和方法学质量评估。使用随机效应模型计算相对风险和标准化均值差。从临床和统计学角度评估合并研究的合理性。在不存在异质性的情况下,计算合并效应量。
在入选的33项试验中,42%为高质量试验。与安慰剂、对照组或其他治疗方法相比,单次手法治疗或多次(3至11周)手法治疗或松动术,或手法治疗与松动术联合使用,在缓解伴有或不伴有头痛的急性/亚急性/慢性MND疼痛方面显示出不显著的益处。有强有力的证据表明,对于伴有或不伴有头痛的亚急性/慢性MND,多模式护理在减轻疼痛[合并标准化均值差(SMD)-0.85(95%置信区间:-1.20至-0.50)]、改善功能[合并SMD -0.57(95%置信区间:-0.94至-0.21)]和整体感知效果[SMD -2.73(95%置信区间:-3.30至-2.16)]方面优于等待名单对照。这种护理策略的共同要素是松动术和/或手法治疗加运动。有中等证据表明,多模式护理与其他各种治疗方法相比,效果无差异。
多模式护理对伴有或不伴有头痛的亚急性/慢性MND有短期和长期持续的益处。这种护理策略的共同要素是松动术和/或手法治疗加运动。证据不支持单独进行手法治疗和/或松动术,或与各种其他物理治疗药物联合使用;相互比较时,两者均不具有优势。对于有神经根症状的颈部疾病,没有足够的证据得出结论。运动的附加益处需要进一步探索。析因设计将有助于确定治疗组合中的有效治疗药物。II期试验将有助于确定最有效的治疗特征和剂量。需要更加关注方法学质量。