Yassen H, Boutroy M J, Monin P, Vert P
INSERM U272, Maternité Régionale Universitaire, Nancy.
Arch Fr Pediatr. 1992 Apr;49(4):351-5.
A prospective study of the hemodynamic and renal changes was undertaken in 11 neonates whose mothers were treated with acebutolol for hypertension during pregnancy, compared with a control group of 11 infants born to normotensive mothers. Monitoring of the cardio-respiratory system was performed for a period of 4 days. Renal function was studied during 2 periods (12-36, 60-84 hours of life). Hemodynamic failure was observed in 5 of 11 children from treated mothers. The data concerning the renal function of treated group showed: 1) a diuresis significantly lower during the first period (p less than 0.05); 2) the absence of significant rise in the glomerular filtration rates during the second period; 3) a lower sodium balance during the 1st and 2nd periods (p less than 0.02 and p less than 0.05), a lower calcium balance during the 1st period (p less than 0.01). No relationship was found between the renal changes and the hemodynamic disturbances. The direct effect of the drug on the glomerular and tubular functions and/or the renal arteriolar vasomotricity could explain these changes in the renal function in the newborns prenatally exposed to acebutolol.
对11名母亲在孕期因高血压接受醋丁洛尔治疗的新生儿进行了血流动力学和肾脏变化的前瞻性研究，并与11名血压正常母亲所生婴儿的对照组进行比较。对心血管呼吸系统进行了为期4天的监测。在两个时间段（出生后12 - 36小时、60 - 84小时）研究了肾功能。在接受治疗母亲所生的11名儿童中，有5名出现了血流动力学衰竭。治疗组的肾功能数据显示：1）在第一个时间段尿量显著降低（p < 0.05）；2）在第二个时间段肾小球滤过率没有显著升高；3）在第一和第二个时间段钠平衡较低（p < 0.02和p < 0.05），在第一个时间段钙平衡较低（p < 0.01）。未发现肾脏变化与血流动力学紊乱之间存在关联。药物对肾小球和肾小管功能及/或肾小动脉血管舒缩功能的直接作用可以解释产前接触醋丁洛尔的新生儿肾功能的这些变化。
