Dumez Y, Tchobroutsky C, Hornych H, Amiel-Tison C
Br Med J (Clin Res Ed). 1981 Oct 24;283(6299):1077-9. doi: 10.1136/bmj.283.6299.1077.
Systolic blood pressure, heart rate, and blood glucose concentration were measured in the first three days of life in 10 infants born to mothers who had received acebutolol, a cardioselective beta-adrenergic-blocking agent, for hypertension in pregnancy and compared with values in 10 infants whose mothers had received methyldopa. The blood pressure was expressed as a percentage of the expected value. Blood pressure was significantly lower in the infants of the mothers given acebutolol (p less than 0.02, less than 0.01, and less than 0.01 respectively during the three days of observation). Heart rate was also lower, but the significance was only at the 0.05 level. Blood glucose was not significantly different between the two groups. These results suggest that care should be taken in prescribing beta-adrenergic-blocking drugs during pregnancy.
对10名母亲在孕期因高血压接受了心脏选择性β-肾上腺素能阻滞剂醋丁洛尔治疗的新生儿，在其出生后的头三天测量了收缩压、心率和血糖浓度，并与10名母亲接受甲基多巴治疗的新生儿的相应数值进行了比较。血压以预期值的百分比表示。接受醋丁洛尔治疗的母亲所生婴儿的血压明显较低（在三天观察期内，分别为p<0.02、<0.01和<0.01）。心率也较低，但显著性仅在0.05水平。两组间血糖无显著差异。这些结果表明，孕期开具β-肾上腺素能阻滞剂时应谨慎。
