Elian J C, Frappaz D, Ros A, Gay J P, Guichard D, Dorche G, Aubert G, Bouteille M, Ollagnier M, Freycon F
Service de Chimiothérapie Massive et Greffe de Moelle, Hôpital Nord, St-Priest-en-Jarez.
Arch Fr Pediatr. 1992 Apr;49(4):357-60.
The serum kinetics of vancomycin was studied in two patients aged 3 and 15 years during antibiotic therapy for catheter related sepsis associated with Staphylococcus epidermidis. Vancomycin was administered, simultaneously, by parenteral conventional doses (30 mg/kg/day div q 8 h) and using the antibiotic-lock technique in the infected catheter at a high concentration (150 mg/ml) during one hour, 3 hours after each infusion. Pharmacokinetics data did not show any significant change in the serum kinetics of the antibiotic. The results suggest that delivering a high concentration of vancomycin in the infected catheter using the lock technique may be useful to sterilize infected catheter without toxic effect.
在两名分别为3岁和15岁的患者中，研究了万古霉素在治疗与表皮葡萄球菌相关的导管相关性败血症的抗生素治疗期间的血清动力学。在每次输注后3小时，通过肠外常规剂量（30mg/kg/天，分8小时给药）同时使用抗生素封管技术，以高浓度（150mg/ml）在感染导管中注入万古霉素1小时。药代动力学数据未显示该抗生素血清动力学有任何显著变化。结果表明，使用封管技术在感染导管中输送高浓度万古霉素可能有助于对感染导管进行消毒且无毒性作用。
