Van Hoogmoed Linda M, Drake Christiana M, Snyder Jack R
Department of Surgical & Radiological Sciences, School of Veterinary Medicine, College of Letters and Sciences, University of California, Davis, CA 95616, USA.
Am J Vet Res. 2004 Feb;65(2):220-4. doi: 10.2460/ajvr.2004.65.220.
To determine the in vitro effect of prostaglandin (PG) E2, PGF2alpha, and the nonsteroidal anti-inflammatory drugs (NSAIDs) indomethacin, ketoprofen, and nabumetone on the contractile strength of the circular smooth muscle layer of the third compartment of the stomach of llamas.
Specimens of the third compartment obtained from 5 healthy adult llamas.
Full-thickness tissue samples were collected from the third compartment immediately after euthanasia. Specimens were cut into strips oriented along the circular muscle layer and mounted in a tissue bath system. Incremental amounts of ketoprofen, nabumetone, indomethacin, PGE2, and PGF2alpha were added, and contractile strength (amplitude of contractions) was recorded.
Generally, PGE2 reduced contractile strength of the circular smooth layer of the third compartment, whereas PGF2alpha, increased the strength of contractions. The activity of the NSAIDs was generally excitatory in a concentration-dependent manner, although significant changes were induced only by administration of indomethacin.
On isolated smooth muscle strips of the third compartment of llamas, exogenous PGE2 and PGF2alpha had a variable effect on contractile strength. Administration of the NSAIDs did not inhibit contractility and would not be likely to induce stasis of the third compartment in the absence of an underlying disease process.
确定前列腺素（PG）E2、PGF2α以及非甾体抗炎药吲哚美辛、酮洛芬和萘丁美酮对美洲驼胃第三部分环形平滑肌层收缩强度的体外作用。
从5只健康成年美洲驼获取的胃第三部分标本。
安乐死后立即从胃第三部分采集全层组织样本。将标本切成沿环形肌层方向的条带，并安装在组织浴系统中。添加递增剂量的酮洛芬、萘丁美酮、吲哚美辛、PGE2和PGF2α，并记录收缩强度（收缩幅度）。
一般来说，PGE2降低胃第三部分环形平滑肌层的收缩强度，而PGF2α增加收缩强度。非甾体抗炎药的活性通常呈浓度依赖性兴奋作用，不过仅吲哚美辛给药可引起显著变化。
在美洲驼胃第三部分的离体平滑肌条带上，外源性PGE2和PGF2α对收缩强度有不同影响。在无潜在疾病过程的情况下，非甾体抗炎药的给药不会抑制收缩力，也不太可能导致胃第三部分淤滞。
