Lee Okhee, Moon Jongwha, Chung Yongsam
Department of Food Science and Nutrition, Yongin University, Samgadong 470, Yongin 449-714 Kyeunggi-do, Korea.
J Nutr Sci Vitaminol (Tokyo). 2003 Dec;49(6):397-404. doi: 10.3177/jnsv.49.397.
Low selenium status draws much attention because of the possible involvement in the etiology of cardiovascular disease (CVD). Hyperlipidmia or dyslipidemia, a very important risk factor for CVD, occurs frequently in middle-aged Koreans. While selenium deficiency is supposed to aggravate blood lipid profiles, it has been shown that selenium status diminishes with advanced age. However, little is known about the selenium status of Koreans, its age-related change, and its relationship to blood lipid levels. In this study the serum selenium level of females according to age and its association with blood lipid profiles were examined. Serum selenium concentration was determined by the instrumental neutron activation analysis method (INAA) using the HANARO research reactor. The overall proportion of women having selenium deficiency, with less than 80.0 microg/L of the selenium concentrations in the serum, was 18.3%. The serum selenium levels in the young-adult. middle-aged and elderly groups were 120.6 microg/L, 97.2 microg/L, and 90.8 microg/L, respectively. Biochemical indices derived from serum selenium levels showed that subjects with the lowest tertile of selenium concentration had significantly higher atherogenic index and lower HDL-cholesterol levels compared to those with the highest tertile. However, only the serum HDL-cholesterol level showed the dependency on the selenium status as determined by step-wise analysis in the subjects below the age of 40. It was noted that in the subjects over the age of 40 (pooled middle-aged and elderly), any dependency of serum lipid profiles on the selenium status was not observed. The results of this study indicated that there is a decreasing tendency of selenium levels with age and that selenium status is associated with blood lipid levels only in young-adult females.
低硒状态因可能参与心血管疾病（CVD）的病因形成而备受关注。高脂血症或血脂异常是CVD的一个非常重要的危险因素，在中年韩国人当中频繁出现。虽然硒缺乏被认为会加重血脂状况，但已有研究表明，硒状态会随着年龄增长而降低。然而，关于韩国人的硒状态、其与年龄相关的变化以及其与血脂水平的关系，人们了解甚少。在本研究中，对不同年龄女性的血清硒水平及其与血脂状况的关联进行了检测。血清硒浓度采用利用韩国原子能研究所研究反应堆的仪器中子活化分析方法（INAA）测定。血清硒浓度低于80.0微克/升的女性中，硒缺乏者的总体比例为18.3%。青年、中年和老年组的血清硒水平分别为120.6微克/升、97.2微克/升和90.8微克/升。源自血清硒水平的生化指标显示，与硒浓度处于最高三分位数的受试者相比，处于最低三分位数的受试者具有显著更高的动脉粥样硬化指数和更低的高密度脂蛋白胆固醇水平。然而，在40岁以下的受试者中，通过逐步分析确定，只有血清高密度脂蛋白胆固醇水平显示出对硒状态的依赖性。值得注意的是，在40岁以上的受试者（中年和老年合并）中，未观察到血脂状况对硒状态的任何依赖性。本研究结果表明，硒水平随年龄增长有下降趋势，且仅在青年女性中，硒状态与血脂水平相关。
