利用数量性状的无模型LOD评分分析，在弗雷明汉姆家系中定位影响血压的基因座。
Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait.
作者信息
Knight Jo, North Bernard V, Sham Pak C, Curtis David
机构信息
Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College, London, United Kingdom.
出版信息
BMC Genet. 2003 Dec 31;4 Suppl 1(Suppl 1):S74. doi: 10.1186/1471-2156-4-S1-S74.
Abstract
This paper presents a method of performing model-free LOD-score based linkage analysis on quantitative traits. It is implemented in the QMFLINK program. The method is used to perform a genome screen on the Framingham Heart Study data. A number of markers that show some support for linkage in our study coincide substantially with those implicated in other linkage studies of hypertension. Although the new method needs further testing on additional real and simulated data sets we can already say that it is straightforward to apply and may offer a useful complementary approach to previously available methods for the linkage analysis of quantitative traits.
摘要
本文提出了一种对数量性状进行基于无模型LOD评分的连锁分析方法。它在QMFLINK程序中实现。该方法用于对弗雷明汉心脏研究数据进行全基因组筛查。在我们的研究中显示出一些连锁支持的许多标记与其他高血压连锁研究中涉及的标记基本一致。尽管新方法需要在更多真实和模拟数据集上进一步测试，但我们已经可以说它应用起来很简单，并且可能为之前用于数量性状连锁分析的方法提供一种有用的补充方法。
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