Moslehi Roxana, Goldstein Alisa M, Beerman Michael, Goldin Lynn, Bergen Andrew W
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland, USA.
BMC Genet. 2003 Dec 31;4 Suppl 1(Suppl 1):S97. doi: 10.1186/1471-2156-4-S1-S97.
Genome-wide scan data from a community-based sample was used to identify the genetic factors that affect body mass index (BMI). BMI was defined as weight (kg) over the square of height (m), where weight and height were obtained from the first measurement available between the ages of 40 and 50 years.
Significant familial correlations were observed in mother:father (spouse) relative pairs and in all relative pairs examined except parent:daughter pairs. Single-point sib-pair regression analysis provided nominal evidence for linkage (p < 0.05) of loci to BMI at 23 markers. Multi-point sib-pair regression analysis provided nominal evidence for linkage to BMI at 42 loci on 12 chromosomes. Empirical p-values showed results consistent with the multi-point results; all but three of the loci identified by multi-point analysis were also significant.
The largest regions of nominally significant linkage were found on chromosomes 2, 3, and 11. The most significant evidence for linkage was obtained with markers D2S1788, D2S1356, D2S1352, D3S1744, and D11S912 from multi-point sib-pair single-trait regression analysis. Our results are in agreement with some of the recently published reports on BMI using various data sets including the Framingham Heart Study data.
基于社区样本的全基因组扫描数据被用于识别影响体重指数（BMI）的遗传因素。BMI的定义为体重（千克）除以身高（米）的平方，其中体重和身高数据取自40至50岁之间首次测量的数据。
在母亲与父亲（配偶）相对的亲属对以及除父母与女儿对之外的所有被检查亲属对中均观察到显著的家族相关性。单点同胞对回归分析为23个标记位点与BMI的连锁提供了名义证据（p < 0.05）。多点同胞对回归分析为12条染色体上的42个位点与BMI的连锁提供了名义证据。经验p值显示结果与多点分析结果一致；多点分析确定的位点中除三个之外其余均具有显著性。
在2号、3号和11号染色体上发现了名义上显著连锁的最大区域。通过多点同胞对单性状回归分析，使用标记D2S1788、D2S1356、D2S1352、D3S1744和D11S912获得了最显著的连锁证据。我们的结果与最近发表的一些使用包括弗雷明汉心脏研究数据在内的各种数据集的关于BMI的报告一致。
