弗明汉心脏研究中胆固醇和甘油三酯水平的双变量连锁分析。
Bivariate linkage analysis of cholesterol and triglyceride levels in the Framingham Heart Study.
作者信息
Zhang Xuyang, Wang Kai
机构信息
Department of Biostatistics, Division of Statistical Genetics, The University of Iowa, Iowa City, Iowa, USA.
出版信息
BMC Genet. 2003 Dec 31;4 Suppl 1(Suppl 1):S62. doi: 10.1186/1471-2156-4-S1-S62.
We performed a bivariate analysis on cholesterol and triglyceride levels on data from the Framingham Heart Study using a new score statistic developed for the detection of potential pleiotropic, or cluster, genes. Univariate score statistics were also computed for each trait. At a significance level 0.001, linkage signals were found at markers GATA48B01 on chromosome 1, GATA21C12 on chromosome 8, and ATA55A11 on chromosome 16 using the bivariate analysis. At the same significance level, linkage signals were found at markers 036yb8 on chromosome 3 and GATA3F02 on chromosome 12 using the univariate analysis. A strong linkage signal was also found at marker GATA112F07 by both the bivariate analysis and the univariate analysis, a marker for which evidence for linkage had been reported previously in a related study.
我们使用一种新的评分统计方法，对弗雷明汉心脏研究的数据进行了胆固醇和甘油三酯水平的双变量分析，该方法用于检测潜在的多效性或聚类基因。还为每个性状计算了单变量评分统计量。在显著性水平为0.001时，使用双变量分析在1号染色体上的GATA48B01、8号染色体上的GATA21C12和16号染色体上的ATA55A11标记处发现了连锁信号。在相同的显著性水平下，使用单变量分析在3号染色体上的036yb8和12号染色体上的GATA3F02标记处发现了连锁信号。通过双变量分析和单变量分析在GATA112F07标记处也发现了强连锁信号，在之前的一项相关研究中曾报道过该标记存在连锁证据。
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