Xu Ai-e, Wei Xiao-dong
Department of Dermatology, Third People's Hospital of Hangzhou, Hangzhou 310009, China.
Chin Med J (Engl). 2004 Feb;117(2):199-201.
The purpose of this study was to evaluate the efficacy of topical melagenine for repigmentation in child patients with vitiligo on the scalp.
Twenty-two child patients with vitiligo on the scalp were treated with 1.2 mg/ml aqueous melagenine in combination with 20 minutes of infrared exposure twice daily.
In 4 patients (18.2%), melagenine treatment in combination with infrared exposure led to complete recovery; in 6 patients (27.3%), treatment was shown to be effective; in 8 patients (36.3%), treatment led to improvements in patient condition; and only 4 patients (18.2%) showed no response after 1 - 2 treatment sessions. The general effective rate of melagenine-infrared combination treatment was 45.5% for the children with vitiligo on the scalp, and treatment was accompanied by minimal side effects.
Melagenine may be efficacious and a safe treatment option for childhood vitiligo affecting the scalp.
本研究旨在评估外用美拉吉宁对头皮白癜风患儿色素再生的疗效。
22例头皮白癜风患儿接受1.2mg/ml美拉吉宁水溶液治疗，并结合每日两次20分钟的红外线照射。
4例（18.2%）患儿经美拉吉宁联合红外线照射治疗后完全康复；6例（27.3%）治疗显示有效；8例（36.3%）治疗后病情改善；仅4例（18.2%）患儿在1 - 2个疗程治疗后无反应。美拉吉宁联合红外线治疗头皮白癜风患儿的总有效率为45.5%，且治疗伴随的副作用极小。
美拉吉宁可能是治疗儿童头皮白癜风的一种有效且安全的选择。
