Jungnitz S, Hiepe F, Kiessig S T, Jungmann R, Hiepe T
Institut für Parasitologie, Veterinärmedizinischen Fakultät, Klinik für Innere Medizin, Theodor Brugsch, Humboldt-Universität, Berlin.
Berl Munch Tierarztl Wochenschr. 1992 Jun 1;105(6):197-201.
In the course of the Trypanosoma equiperdum-infection of mice an increase of IgM antibodies against the autoantigens dsDNA, keratin and collagen as well as against a protozoan foreign antigen consisting of Sarcocystis gigantea-extract could be observed with a maximum level between 4th and 8th day p. i. The IgG-antibodies did not significantly change during the investigation time. A splenomegaly appeared after the infection. The weight of spleen was four times higher than normal. It was suggested that splenomegaly as well as induction of antibodies against several autoantigens and a foreign antigen were due to a polyclonal activation of lymphocytes.
在小鼠感染马媾疫锥虫的过程中，可观察到针对自身抗原双链DNA、角蛋白和胶原蛋白以及针对由巨型肉孢子虫提取物组成的原生动物外来抗原的IgM抗体增加，在感染后第4天至第8天达到最高水平。在研究期间，IgG抗体没有显著变化。感染后出现脾肿大。脾脏重量比正常高四倍。有人提出，脾肿大以及针对几种自身抗原和一种外来抗原的抗体诱导是由于淋巴细胞的多克隆激活。
