Noël Georges, Boisserie Gilbert, Feuvret Loïc, Mazeron Jean-Jacques
Centre de protonthétapie d'Orsay, France.
Bull Cancer. 2004 Jan;91(1):81-93.
The quantity of results published since the development of the radiochirurgie does not always lead to consider overall the consequences of the introduction of this treatment into the therapeutic arsenal of the clinician. The role of this treatment in front of the surgery, its association with the whole brain radiation therapy, the impact on the survival of this treatment and the incorporation of the various prognostic factors to the therapeutic decision are some one of the unresolved question. Best indications of radiosurgery concern probably patient with a good performance status, without extra-cranial disease and presenting no more than 4 metastasis. However, in an obviously palliative context, any dogmatism must be avoided. Development of prospective trials is the best solution to well specify the indication of the technique.
自从放射外科发展以来所发表的研究结果数量,并不总能促使人们全面考虑将这种治疗方法引入临床医生的治疗手段后所产生的后果。这种治疗方法相对于手术的作用、它与全脑放射治疗的联合应用、对这种治疗方法生存率的影响以及各种预后因素在治疗决策中的纳入,都是尚未解决的问题之一。放射外科的最佳适应证可能是身体状况良好、无颅外疾病且转移灶不超过4个的患者。然而,在明显的姑息治疗情况下,必须避免任何教条主义。开展前瞻性试验是明确该技术适应证的最佳解决方案。