Wulff-Woesten A, Ohlendorf D, Henz B M, Haas N
Department of Dermatology and Allergy, Charité, Humboldt University, Berlin, Germany.
Skin Pharmacol Physiol. 2004 Mar-Apr;17(2):91-7. doi: 10.1159/000076019.
On the scalp, dithranol has been studied in only a few trials. The dithranol molecule that contains both hydrophilic and lipophilic centers can be incorporated into detergents and allows easy removal from hair. This property has led to the incorporation of dithranol in an emulsifying oil base (bio-wash-oil). The formulation has been used routinely for more than two decades in East Germany. We reexamined the efficacy and safety of dithranol in bio-wash-oil and compared it to dithranol embedded in crystalline monoglycerides (Micanol) in patients with psoriasis of the scalp. In a prospective, parallel group study, 64 patients attending a day-care clinic were randomly allocated to 3 treatment groups: (1) dithranol in bio-wash-oil; (2) Micanol cream, and (3) Micanol cream in bio-wash-oil. Treatment was carried out for 3 weeks and results assessed using a modified Psoriasis Area and Severity Index score. Dithranol in bio-wash-oil resulted in a reduction in the score of 34% on day 7 and 57% on day 14. This was significantly better than in groups 2 and 3, as were the overall response and patients' assessment at the end of treatment (p < 0.05). Dithranol in a bio-wash-oil is an effective, well-tolerated and low-priced treatment in psoriasis of the scalp.
在头皮上，仅对蒽林进行了少数几项试验。蒽林分子同时含有亲水性和亲脂性中心，可被纳入洗涤剂中，且易于从头发上清除。这一特性使得蒽林被纳入乳化油基质（生物洗油）中。在东德，这种配方已常规使用了二十多年。我们重新审视了生物洗油中蒽林的疗效和安全性，并将其与嵌入结晶单甘油酯（米卡诺醇）中的蒽林在头皮银屑病患者中的情况进行了比较。在一项前瞻性平行组研究中，64名在日间护理诊所就诊的患者被随机分配到3个治疗组：（1）生物洗油中的蒽林；（2）米卡诺醇乳膏；（3）生物洗油中的米卡诺醇乳膏。治疗进行3周，并使用改良的银屑病面积和严重程度指数评分评估结果。生物洗油中的蒽林在第7天使评分降低了34%，在第14天降低了57%。这明显优于第2组和第3组，治疗结束时的总体反应和患者评估也是如此（p<0.05）。生物洗油中的蒽林是治疗头皮银屑病的一种有效、耐受性良好且价格低廉的疗法。
