人类免疫缺陷病毒感染和未感染儿童中持续性细小病毒B19感染且未发展为慢性贫血：母婴传播研究

Persistent parvovirus B19 infection without the development of chronic anemia in HIV-infected and -uninfected children: the Women and Infants Transmission Study.

作者信息

LaMonte Ashley C, Paul Mary E, Read Jennifer S, Frederick Margaret M, Erdman Dean D, Han Linda L, Anderson Larry J

机构信息

Respiratory and Enteric Viruses Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.

出版信息

J Infect Dis. 2004 Mar 1;189(5):847-51. doi: 10.1086/381899. Epub 2004 Feb 9.

DOI:10.1086/381899

PMID:14976602

Abstract

We evaluated the prevalence of persistent parvovirus B19 (B19) infection and associated anemia in human immunodeficiency virus (HIV)-infected and HIV-uninfected children. B19 persistence was defined as B19 DNA detected in specimens collected >16 weeks apart. Of 182 children, 3 HIV-infected children and two HIV-uninfected children had evidence of persistent B19 infection. Of the 5 children, none had evidence of B19-associated anemia. Our data suggest that B19 infections can persist in children without the development of symptomatic anemia.

摘要

我们评估了人类免疫缺陷病毒（HIV）感染儿童和未感染HIV儿童中持续性细小病毒B19（B19）感染及相关贫血的患病率。B19持续性感染定义为在间隔超过16周采集的标本中检测到B19 DNA。在182名儿童中，3名HIV感染儿童和2名未感染HIV儿童有持续性B19感染的证据。在这5名儿童中，没有人有B19相关贫血的证据。我们的数据表明，B19感染可在儿童中持续存在而不出现症状性贫血。