Ziyaeyan Mazyar, Rasouli Manoochehr, Alborzi Abdolvahab
Prof. Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Namazi General Hospital, Shiraz, Iran.
Jpn J Infect Dis. 2005 Apr;58(2):95-7.
Erythema infectiosum (fifth Disease) is the major clinical manifestation of human parvovirus B19 (HPV B19) infection. HPV B19 is known to be associated with adverse effects on fetuses such as hydrops fetalis, aplastic anemia, intrauterine fetal death, and chronic anemia in immunocompromised individuals. The objective of this study was to assess seroprevalence to HPV B19 in three different groups in Shiraz, Iran. The first group included 91 to-be-married girls. The second group included 184 pregnant women and the third group consisted of 184 neonates, who were born to the women in the second group. Specific IgG and IgM antibodies to HPV B19 were measured using ELISA technique. Results showed that the prevalence for IgG to HPV B19 was 56 (61.5%), 127 (69%), and 127 (69%) for the first, second, and third groups, respectively. Overall, 183 out of the 275 (66.5%) women of childbearing age had IgG to HPV B19. The seroprevalence for IgM to HPV B19 was 2.2% for the second group. There was no detectable IgM in umbilical cord sera or in the first group blood samples. In conclusion, approximately one-third of individuals in the study who were of childbearing age were at risk for primary HPV B19 infection.
传染性红斑（第五病）是人类细小病毒B19（HPV B19）感染的主要临床表现。已知HPV B19会对胎儿产生不良影响，如胎儿水肿、再生障碍性贫血、宫内胎儿死亡以及免疫功能低下个体的慢性贫血。本研究的目的是评估伊朗设拉子三个不同群体中HPV B19的血清流行率。第一组包括91名待嫁女孩。第二组包括184名孕妇，第三组由第二组妇女所生的184名新生儿组成。使用酶联免疫吸附测定（ELISA）技术检测HPV B19的特异性IgG和IgM抗体。结果显示，第一、第二和第三组中HPV B19 IgG的流行率分别为56（61.5%）、127（69%）和127（69%）。总体而言，275名育龄妇女中有183名（66.5%）HPV B19 IgG呈阳性。第二组中HPV B19 IgM的血清流行率为2.2%。脐带血清或第一组血液样本中未检测到IgM。总之，该研究中约三分之一的育龄个体有原发性HPV B19感染的风险。
