Brabin Loretta, Roberts Chris, Barr Fiona, Agbaje Shola, Harper Gregory, Briggs Nimi
Departments of Obstetrics and Gynaecology and Reproductive Health Care and of Epidemiology and Health Sciences, University of Manchester, Manchester, U.K.
J Reprod Med. 2004 Jan;49(1):41-51.
To describe the pattern and relation of sex serum hormones and retinol concentrations over 1 menstrual cycle in adolescent girls living in a resource-poor setting.
Venous blood samples were collected on alternate days of the cycle, and estrogen, progesterone, luteinizing hormone (LH), follicle stimulating hormone and serum retinol were measured. A linear random effects model was used to examine the relationship between sex hormones and serum retinol.
Twenty-eight girls were studied. During the follicular phase, serum retinol was associated negatively with progesterone and positively with LH. In the luteal phase, serum retinol was positively associated with estrogen. Serum retinol increased in the follicular phase but not the luteal phase. Sex hormone and serum retinol concentrations showed marked individual and day-to-day variability. Two girls maintained serum retinol concentrations > 0.7 mumol/L throughout the cycle. Six remained at < 0.7 mumol/L, which indicated subclinical deficiency.
This study indicated that in adolescent girls, sex hormone patterns correlate significantly with serum retinol, and in vitamin A-deficient girls this could be important for reproductive function.
描述生活在资源匮乏地区的青春期女孩在一个月经周期内血清性激素和视黄醇浓度的变化模式及关系。
在月经周期的隔日采集静脉血样，检测雌激素、孕激素、黄体生成素（LH）、卵泡刺激素和血清视黄醇。采用线性随机效应模型研究性激素与血清视黄醇之间的关系。
对28名女孩进行了研究。在卵泡期，血清视黄醇与孕激素呈负相关，与LH呈正相关。在黄体期，血清视黄醇与雌激素呈正相关。血清视黄醇在卵泡期升高，但在黄体期未升高。性激素和血清视黄醇浓度显示出明显的个体差异和每日波动。两名女孩在整个周期中血清视黄醇浓度均>0.7 μmol/L。六名女孩的血清视黄醇浓度保持在<0.7 μmol/L，表明存在亚临床缺乏。
本研究表明，在青春期女孩中，性激素模式与血清视黄醇显著相关，在维生素A缺乏的女孩中，这可能对生殖功能很重要。
