Bergemann Niels, Parzer Peter, Runnebaum Benno, Resch Franz, Mundt Christoph
Department of General Psychiatry, University of Heidelberg, Heidelberg, Germany.
Psychol Med. 2007 Oct;37(10):1427-36. doi: 10.1017/S0033291707000578. Epub 2007 Apr 24.
Estrogen has been hypothesized to have a protective and antipsychotic-like effect in women at risk for schizophrenia. The aim of the present study was to evaluate the association between menstrual cycle and/or estrogen levels and psychotic symptoms in a sample of women with schizophrenia.
One hundred and twenty-five premenopausal women with schizophrenia and regular menses were examined. The levels of 17beta-estradiol and other hormones of the gonadal axis were assessed in the follicular, peri-ovulatory, and luteal phases of the menstrual cycle. The effects of the menstrual cycle phase and/or the estradiol level on the Positive and Negative Syndrome Scale (PANSS) and the Brief Psychiatric Rating Scale (BPRS) scores were calculated by means of regression analyses.
Significant improvement in psychotic, but not depressive, symptoms was observed during the luteal phase, compared with other days of the menstrual cycle.
The present findings indicate that estradiol may have specific antipsychotic-like effects on the symptoms of schizophrenia. Thus further investigation into the therapeutic effect of estrogen may be worthwhile.
有假说认为雌激素对有精神分裂症风险的女性具有保护作用及类似抗精神病的效果。本研究的目的是评估精神分裂症女性样本中月经周期和/或雌激素水平与精神病症状之间的关联。
对125名绝经前精神分裂症且月经规律的女性进行检查。在月经周期的卵泡期、排卵期和黄体期评估17β-雌二醇及性腺轴其他激素的水平。通过回归分析计算月经周期阶段和/或雌二醇水平对阳性和阴性症状量表（PANSS）及简明精神病评定量表（BPRS）评分的影响。
与月经周期的其他日子相比，在黄体期观察到精神病症状有显著改善，但抑郁症状无改善。
本研究结果表明，雌二醇可能对精神分裂症症状具有特定的类似抗精神病的作用。因此，进一步研究雌激素的治疗效果可能是值得的。
