Ridnour Lisa A, Thomas Douglas D, Mancardi Daniele, Espey Michael G, Miranda Katrina M, Paolocci Nazareno, Feelisch Martin, Fukuto Jon, Wink David A
Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Biol Chem. 2004 Jan;385(1):1-10. doi: 10.1515/BC.2004.001.
This review addresses many of the chemical aspects of nitrosative stress mediated by N2O3. From a cellular perspective, N2O3 and the resulting reactive nitrogen oxide species target specific motifs such as thiols, lysine active sites, and zinc fingers and is dependant upon both the rates of production as well as consumption of NO and must be taken into account in order to access the nitrosative environment. Since production and consumption are integral parts of N2O3 generation, we predict that nitrosative stress occurs under specific conditions, such as chronic inflammation. In contrast to conditions of stress, nitrosative chemistry may also provide cellular protection through the regulation of critical signaling pathways. Therefore, a careful evaluation of the chemistry of nitrosation based upon specific experimental conditions may provide a better understanding of how the subtle balance between oxidative and nitrosative stress may be involved in the etiology and control of various disease processes.
本综述探讨了由三氧化二氮介导的亚硝化应激的许多化学方面。从细胞角度来看，三氧化二氮及由此产生的活性氮氧化物靶向特定基序，如硫醇、赖氨酸活性位点和锌指，并且取决于一氧化氮的产生速率和消耗速率，为了了解亚硝化环境，必须考虑这些因素。由于产生和消耗是三氧化二氮生成的组成部分，我们预测亚硝化应激会在特定条件下发生，如慢性炎症。与应激条件相反，亚硝化化学也可能通过调节关键信号通路提供细胞保护。因此，基于特定实验条件对亚硝化化学进行仔细评估，可能有助于更好地理解氧化应激和亚硝化应激之间的微妙平衡如何参与各种疾病过程的病因和控制。
