Shannon John M, Hyatt Brian A
Division of Pulmonary Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA.
Annu Rev Physiol. 2004;66:625-45. doi: 10.1146/annurev.physiol.66.032102.135749.
Classical experiments in embryology have shown that normal growth, morphogenetic patterning, and cellular differentiation in the developing lung depend on interactive signaling between the endodermal epithelium and mesenchyme derived from splanchnic mesoderm. These interactions are mediated by a myriad of diffusible factors that are precisely regulated in their temporal and spatial expression. In this review we first describe factors regulating formation of the embryonic foregut. We then discuss the experiments demonstrating the importance of tissue interactions in lung patterning and differentiation. Finally, we detail the roles that a few key signaling systems-fibroblast growth factors and their receptors, sonic hedgehog and Gli genes, Wnt genes and beta-catenin, and BMP4-play as mediators of epithelial-mesenchymal interactions in the developing lung.
胚胎学的经典实验表明，发育中的肺的正常生长、形态发生模式和细胞分化取决于内胚层上皮与源自脏壁中胚层的间充质之间的相互信号传导。这些相互作用由大量可扩散因子介导，这些因子在其时间和空间表达上受到精确调控。在这篇综述中，我们首先描述调节胚胎前肠形成的因子。然后我们讨论证明组织相互作用在肺模式形成和分化中的重要性的实验。最后，我们详细阐述一些关键信号系统——成纤维细胞生长因子及其受体、音猬因子和Gli基因、Wnt基因和β-连环蛋白以及BMP4——作为发育中的肺上皮-间充质相互作用介质所起的作用。
