SUMOylation 在肺部疾病中的新兴作用。
The emerging roles of SUMOylation in pulmonary diseases.
机构信息
Department of pediatrics, The Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310000, Zhejiang, P.R. China.
Department of Orthopedics Surgery, The Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 31000, Zhejiang, P.R. China.
出版信息
Mol Med. 2023 Sep 5;29(1):119. doi: 10.1186/s10020-023-00719-1.
Small ubiquitin-like modifier mediated modification (SUMOylation) is a critical post-translational modification that has a broad spectrum of biological functions, including genome replication and repair, transcriptional regulation, protein stability, and cell cycle progression. Perturbation or deregulation of a SUMOylation and deSUMOylation status has emerged as a new pathophysiological feature of lung diseases. In this review, we highlighted the link between SUMO pathway and lung diseases, especially the sumoylated substrate such as C/EBPα in bronchopulmonary dysplasia (BDP), PPARγ in pneumonia, TFII-I in asthma, HDAC2 in chronic obstructive pulmonary disease (COPD), KLF15 in hypoxic pulmonary hypertension (HPH), SMAD3 in idiopathic pulmonary fibrosis (IPF), and YTHDF2 in cancer. By exploring the impact of SUMOylation in pulmonary diseases, we intend to shed light on its potential to inspire the development of innovative diagnostic and therapeutic strategies, holding promise for improving patient outcomes and overall respiratory health.
小泛素样修饰物介导的修饰（SUMOylation）是一种关键的翻译后修饰，具有广泛的生物学功能，包括基因组复制和修复、转录调控、蛋白质稳定性和细胞周期进程。SUMOylation 和去 SUMOylation 状态的干扰或失调已成为肺部疾病的新病理生理学特征。在这篇综述中，我们强调了 SUMO 通路与肺部疾病之间的联系，特别是 SUMO 化底物，如支气管肺发育不良（BDP）中的 C/EBPα、肺炎中的 PPARγ、哮喘中的 TFII-I、慢性阻塞性肺疾病（COPD）中的 HDAC2、低氧性肺动脉高压（HPH）中的 KLF15、特发性肺纤维化（IPF）中的 SMAD3 和癌症中的 YTHDF2。通过探索 SUMOylation 在肺部疾病中的影响，我们旨在阐明其启发创新诊断和治疗策略的潜力，有望改善患者的预后和整体呼吸健康。
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