McRobbie Donald W, Pritchard Susan, Quest Rebecca A
Radiological Sciences Unit, The Hammersmith Hospital NHS Trust & Imperial College, Charing Cross Hospital, London, United Kingdom.
J Aerosol Med. 2003 Winter;16(4):401-15. doi: 10.1089/089426803772455668.
The oropharyngeal region of the human airways has been scanned using 3D MRI and the data used to produce a model cast. The scanning method used a triggering device, which enabled data collection at the same pressure drop in each breathing cycle to produce clear images free of motion-related artefacts. A comparison between two differing MR acquisition strategies was made in a single subject, multi-session study. 3D FISP MR imaging was found to produce the most reliable data. Excluding the buccal cavity, where tongue position was critical, the reproducibility of measured airway volumes and cross sectional areas between sessions was demonstrated. Inter-session total airway volume (excluding the mouth) reproducibility was of the order of 5% and for minimum cross sectional areas at the epiglottis and vocal cords was 10%. The production of a physical cast from the images led to a 5% increase in airway volume compared with the anatomical images but with some loss of fine detail. The data demonstrated the robustness of an ex-vivo means of studying oropharyngeal dimensions and dynamics which may contribute to advancements in the understanding of aerosol delivery of therapeutic agents.
已使用三维磁共振成像（3D MRI）对人类气道的口咽区域进行扫描，并利用所得数据制作模型铸件。扫描方法采用了触发装置，可在每个呼吸周期的相同压降条件下收集数据，从而生成无运动相关伪影的清晰图像。在一项针对单一受试者的多阶段研究中，对两种不同的磁共振采集策略进行了比较。结果发现，三维快速成像稳态进动序列（3D FISP）磁共振成像可产生最可靠的数据。除了颊腔（舌位置在此处至关重要）外，各阶段之间气道容积和横截面积测量值的可重复性得到了证实。各阶段之间总气道容积（不包括口腔）的可重复性约为5%，会厌和声带上最小横截面积的可重复性为10%。由图像制作实体铸件后，气道容积比解剖图像增加了5%，但精细细节有所损失。这些数据证明了一种用于研究口咽尺寸和动力学的体外方法的稳健性，这可能有助于推动对治疗药物气溶胶递送的理解。
