多发性硬化症中免疫介导的神经退行性变与神经保护作用

Immune-mediated neurodegeneration and neuroprotection in MS.

作者信息

Giuliani F, Yong V W

机构信息

University of Calgary, Department of Clinical Neurosciences, 3330 Hospital Drive, Calgary, Alberta, T2N 4N1, Canada.

出版信息

Int MS J. 2003 Dec;10(4):122-30.

PMID:14977489

Abstract

It has become evident that multiple sclerosis (MS) has significant neurodegenerative components. An increasing number of reports show neuronal and axonal damage in MS patients and experimental allergic encephalomyelitis (EAE) in an animal model of MS. The mechanisms behind this neurodegeneration are unknown, but evidence suggests immune-mediated damage. In this review we analyse the findings of immune-mediated injury in MS and focus on axonal and neuronal injury. The potential neuroprotective role of some currently available MS drug treatments is also discussed.

摘要

多发性硬化症（MS）具有显著的神经退行性成分，这一点已变得显而易见。越来越多的报告显示，MS患者以及MS动物模型实验性自身免疫性脑脊髓炎（EAE）中存在神经元和轴突损伤。这种神经退行性变背后的机制尚不清楚，但有证据表明是免疫介导的损伤。在本综述中，我们分析了MS中免疫介导损伤的研究结果，并重点关注轴突和神经元损伤。还讨论了一些目前可用的MS药物治疗的潜在神经保护作用。