Schwartz Michal, Butovsky Oleg, Kipnis Jonathan
Department of Neurobiology, The Weizmann Institute of Science, 76100, Rehovot, Israel.
J Neuroimmune Pharmacol. 2006 Mar;1(1):4-10. doi: 10.1007/s11481-005-9010-2.
Accumulating evidence suggests that neurodegenerative diseases of the central nervous system (CNS) are associated with a local inflammatory response. CNS autoimmune diseases are also associated with inflammation. Does this mean that all neurodegenerative diseases are autoimmune in nature? Does it imply that autoimmune and neurodegenerative diseases are both eligible for the same therapy? What distinguishes between the two types of disease? Do they differ both in etiology and in pathology, or do they have different etiologies but similar pathology and progression? In this minireview we offer a new view of the inflammatory differences between neurodegenerative and autoimmune diseases in the CNS and discuss the implications for therapy.
越来越多的证据表明，中枢神经系统（CNS）的神经退行性疾病与局部炎症反应有关。中枢神经系统自身免疫性疾病也与炎症有关。这是否意味着所有神经退行性疾病本质上都是自身免疫性的？这是否意味着自身免疫性疾病和神经退行性疾病都适合相同的治疗方法？这两种疾病有何区别？它们在病因和病理上都不同，还是病因不同但病理和进展相似？在这篇迷你综述中，我们提出了关于中枢神经系统中神经退行性疾病和自身免疫性疾病炎症差异的新观点，并讨论了其对治疗的意义。
