非O157血清群产志贺毒素大肠杆菌菌株中细胞致死膨胀毒素基因的鉴定及表达
Characterization of cytolethal distending toxin genes and expression in shiga toxin-producing Escherichia coli strains of non-O157 serogroups.
作者信息
Bielaszewska Martina, Fell Marina, Greune Lilo, Prager Rita, Fruth Angelika, Tschäpe Helmut, Schmidt M Alexander, Karch Helge
机构信息
Institut für Hygiene, Universitätsklinikum Münster, Zentrum für Molekularbiologie der Entzündung (ZMBE), Universität Münster, 48149 Münster, Germany.
出版信息
Infect Immun. 2004 Mar;72(3):1812-6. doi: 10.1128/IAI.72.3.1812-1816.2004.
Abstract
We identified cytolethal distending toxin and its gene (cdt) in 17 of 340 non-O157 Shiga toxin-producing Escherichia coli (STEC) strains (serotypes O73:H18, O91:H21, O113:H21, and O153:H18), all of which were eae negative. cdt is either chromosomal and homologous to cdt-V (serotypes O73:H18, O91:H21, and O113:H21) or plasmidborne and identical to cdt-III (serotype O153:H18). Among eae-negative STEC, cdt was associated with disease (P = 0.003).
摘要
我们在340株非O157产志贺毒素大肠杆菌（STEC）菌株（血清型O73:H18、O91:H21、O113:H21和O153:H18）中的17株中鉴定出细胞致死膨胀毒素及其基因（cdt），所有这些菌株eae均为阴性。cdt要么位于染色体上且与cdt-V同源（血清型O73:H18、O91:H21和O113:H21），要么由质粒携带且与cdt-III相同（血清型O153:H18）。在eae阴性的STEC中，cdt与疾病相关（P = 0.003）。
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