Bielaszewska Martina, Fell Marina, Greune Lilo, Prager Rita, Fruth Angelika, Tschäpe Helmut, Schmidt M Alexander, Karch Helge
Institut für Hygiene, Universitätsklinikum Münster, Zentrum für Molekularbiologie der Entzündung (ZMBE), Universität Münster, 48149 Münster, Germany.
Infect Immun. 2004 Mar;72(3):1812-6. doi: 10.1128/IAI.72.3.1812-1816.2004.
We identified cytolethal distending toxin and its gene (cdt) in 17 of 340 non-O157 Shiga toxin-producing Escherichia coli (STEC) strains (serotypes O73:H18, O91:H21, O113:H21, and O153:H18), all of which were eae negative. cdt is either chromosomal and homologous to cdt-V (serotypes O73:H18, O91:H21, and O113:H21) or plasmidborne and identical to cdt-III (serotype O153:H18). Among eae-negative STEC, cdt was associated with disease (P = 0.003).
我们在340株非O157产志贺毒素大肠杆菌（STEC）菌株（血清型O73:H18、O91:H21、O113:H21和O153:H18）中的17株中鉴定出细胞致死膨胀毒素及其基因（cdt），所有这些菌株eae均为阴性。cdt要么位于染色体上且与cdt-V同源（血清型O73:H18、O91:H21和O113:H21），要么由质粒携带且与cdt-III相同（血清型O153:H18）。在eae阴性的STEC中，cdt与疾病相关（P = 0.003）。
