Rogers E J, Milhalik S, Orthiz D, Shea T B
Center for Cellular Neurobiology and Neurodegeneration Research, Department of Biological Sciences, University of Massachusetts Lowell, One University Avenue, Lowell, MA 01854, USA.
J Nutr Health Aging. 2004;8(2):92-7.
Increased oxidative stress contributes to the decline in cognitive performance during normal aging and in neurodegenerative conditions such as Alzheimer s disease. Dietary supplementation with fruits and vegetables that are high in antioxidant potential have in some cases compensated for dietary and/or genetic deficiencies that promote increased oxidative stress. Herein, we demonstrate that apple juice concentrate, administered ad libitum in drinking water, can compensate for the increased reactive oxygen species and decline in cognitive performance in maze trials observed when normal and transgenic mice lacking apolipoprotein E are deprived of folate and vitamin E. In addition, we demonstrate that this protective effect is not derived from the sugar content of the concentrate.
氧化应激增加会导致正常衰老过程以及诸如阿尔茨海默病等神经退行性疾病中认知能力下降。补充富含抗氧化潜能的水果和蔬菜在某些情况下可弥补促进氧化应激增加的饮食和/或基因缺陷。在此，我们证明，在饮用水中随意添加浓缩苹果汁，可以弥补正常小鼠和缺乏载脂蛋白E的转基因小鼠在缺乏叶酸和维生素E时，迷宫试验中观察到的活性氧增加和认知能力下降。此外，我们证明这种保护作用并非来自浓缩汁中的糖分。
