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苹果及其成分的综合综述及其与人类健康的关系。

A comprehensive review of apples and apple components and their relationship to human health.

机构信息

Department of Family and Consumer Sciences-Nutrition and Food/Dietetics, California State University, Sacramento, CA, USA.

出版信息

Adv Nutr. 2011 Sep;2(5):408-20. doi: 10.3945/an.111.000513. Epub 2011 Sep 6.

DOI:10.3945/an.111.000513
PMID:22332082
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3183591/
Abstract

There has been an increasing appreciation and understanding of the link between dietary fruit and vegetable intake and improved health in humans. The widespread and growing intake of apples and apple juice/products and their rich phytochemical profile suggest their important potential to affect the health of the populations consuming them. This review summarizes current clinical, in vitro, and in vivo data and builds upon earlier published reports that apple may reduce the risk of chronic disease by various mechanisms, including antioxidant, antiproliferative, and cell signaling effects. Exposure to apples and apple products has been associated with beneficial effects on risk, markers, and etiology of cancer, cardiovascular disease, asthma, and Alzheimer's disease. Recent work suggests that these products may also be associated with improved outcomes related to cognitive decline of normal aging, diabetes, weight management, bone health, pulmonary function, and gastrointestinal protection.

摘要

人们越来越认识到,饮食中摄入水果和蔬菜与人类健康的改善之间存在关联。苹果及其丰富的植物化学物质广泛而不断增加的摄入量,表明它们对食用者的健康具有重要的潜在影响。本综述总结了目前的临床、体外和体内数据,并建立在以前发表的报告的基础上,即苹果可能通过抗氧化、抗增殖和细胞信号作用等多种机制降低慢性疾病的风险。接触苹果及其产品与癌症、心血管疾病、哮喘和老年痴呆症的风险、标志物和病因的有益影响有关。最近的研究表明,这些产品还可能与与正常衰老、糖尿病、体重管理、骨骼健康、肺功能和胃肠道保护相关的认知能力下降的改善结果有关。

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J Agric Food Chem. 2009 Mar 11;57(5):2009-15. doi: 10.1021/jf802757x.
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Dietary supplementation with apple juice decreases endogenous amyloid-beta levels in murine brain.苹果汁膳食补充剂可降低小鼠大脑中的内源性β-淀粉样蛋白水平。
J Alzheimers Dis. 2009;16(1):167-71. doi: 10.3233/JAD-2009-0959.
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Fresh apples suppress mammary carcinogenesis and proliferative activity and induce apoptosis in mammary tumors of the Sprague-Dawley rat.新鲜苹果可抑制斯普拉格-道利大鼠乳腺肿瘤的发生、增殖活性并诱导其凋亡。
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Apple phytochemical extracts inhibit proliferation of estrogen-dependent and estrogen-independent human breast cancer cells through cell cycle modulation.苹果植物化学提取物通过调节细胞周期抑制雌激素依赖性和非雌激素依赖性人乳腺癌细胞的增殖。
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