Steger David J, O'Shea Erin K
Howard Hughes Medical Institute, University of California, San Francisco, Department of Biochemistry and Biophysics, San Francisco, California 94143-2240, USA.
Methods Enzymol. 2004;377:55-60. doi: 10.1016/S0076-6879(03)77002-5.
Novel discoveries result from genetic analyses of transcription and chromatin remodeling because these methods identify activities in an unbiased manner. By describing our genetic approaches to identify regulators of PHO5 transcription and chromatin remodeling, we hope to encourage others to apply similar strategies to their genes of interest.
新的发现源于对转录和染色质重塑的遗传分析，因为这些方法能以无偏见的方式识别相关活动。通过描述我们用于识别PHO5转录和染色质重塑调节因子的遗传方法，我们希望鼓励其他人将类似策略应用于他们感兴趣的基因。
