日本严重侵袭性G群链球菌感染的监测及分离株的分子分型
Surveillance of severe invasive group-G streptococcal infections and molecular typing of the isolates in Japan.
作者信息
Ikebe T, Murayama S, Saitoh K, Yamai S, Suzuki R, Isobe J, Tanaka D, Katsukawa C, Tamaru A, Katayama A, Fujinaga Y, Hoashi K, Watanabe H
机构信息
Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan.
出版信息
Epidemiol Infect. 2004 Jan;132(1):145-9. doi: 10.1017/s0950268803001262.
Abstract
The number of patients with severe invasive group-G streptococcal (Streptococcus dysgalactiae subsp. equisimilis) infections has been increasing in Japan. The emm genotypes and SmaI-digested pulsed-field gel electrophoresis DNA profiles were variable among the strains isolated, suggesting there has not been clonal expansion of a specific subpopulation of strains. However, all strains carried scpA, ska, slo and sag genes, some of which may be involved in the pathogenesis of the disease.
摘要
在日本，严重侵袭性G群链球菌（马链球菌兽疫亚种）感染患者的数量一直在增加。在分离出的菌株中，emm基因型和经SmaI酶切的脉冲场凝胶电泳DNA图谱各不相同，这表明没有特定菌株亚群的克隆性扩增。然而，所有菌株都携带scpA、ska、slo和sag基因，其中一些基因可能与该疾病的发病机制有关。
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