García-Fernández Raymid, Pérez-Velasco Javier G, Concepcíon-Millán Ariadna, Sosa Sualy, Navaroli Francisco, García-Barreto David
Institute of Cardiology and Cardiovascular Surgery, Havana, Cuba.
Clin Cardiol. 2004 Feb;27(2):71-3. doi: 10.1002/clc.4960270205.
Estrogen favors endothelial function while acute tobacco use provokes dysfunction. Previous studies have not examined the effect of smoking one cigarette at different stages of the menstrual cycle.
Favorable actions of estrogen on endothelial function are transitorily abolished by smoking one cigarette.
Brachial artery endothelium-dependent dilation was measured noninvasively before, 10 min, and 1 h after smoking in 17 healthy premenopausal women. Studies were done in the first 3 days (early stage) and repeated between Days 9 and 13 of the menstrual cycle (middle stage). Estradiol was measured after each study.
At basal conditions, women in the middle stage of their cycles, when estradiol was 20 times higher than in the early stage, had significantly more endothelial-dependent brachial dilatation. No difference in the marked depression caused by cigarette smoking was found between the two stages. One h recuperation was complete in both phases.
Cigarette smoking abolishes the protection of circulating estrogen on endothelial function.
雌激素有利于内皮功能，而急性吸烟会引发功能障碍。以往研究未考察在月经周期不同阶段吸一支烟的影响。
吸一支烟会暂时消除雌激素对内皮功能的有益作用。
对17名健康绝经前女性在吸烟前、吸烟后10分钟和1小时无创测量肱动脉内皮依赖性舒张功能。研究在月经周期的前3天（早期）进行，并在月经周期的第9至13天（中期）重复。每次研究后测量雌二醇水平。
在基础状态下，处于月经周期中期的女性，其雌二醇水平比早期高20倍，具有显著更多的内皮依赖性肱动脉舒张。两个阶段之间在吸烟引起的明显抑制方面未发现差异。两个阶段在1小时后均完全恢复。
吸烟会消除循环雌激素对内皮功能的保护作用。
