Maren Stephen, Holt William G
Department of Psychology, Neuroscience Program, University of Michigan, Ann Arbor, MI 48109-1109, USA.
Behav Neurosci. 2004 Feb;118(1):97-110. doi: 10.1037/0735-7044.118.1.97.
The authors compared the effects of pharmacological inactivation of the dorsal hippocampus (DH) or ventral hippocampus (VH) on Pavlovian fear conditioning in rats. Freezing behavior served as the measure of fear. Pretraining infusions of muscimol, a GABAA receptor agonist, into the VH disrupted auditory, but not contextual, fear conditioning; DH infusions did not affect fear conditioning. Pretesting inactivation of the VH or DH did not affect the expression of conditional freezing. Pretraining electrolytic lesions of the VH reproduced the effects of muscimol infusions, whereas posttraining VH lesions disrupted both auditory and contextual freezing. Hence, neurons in the VH are importantly involved in the acquisition of auditory fear conditioning and the expression of auditory and contextual fear under some conditions.
作者比较了背侧海马体（DH）或腹侧海马体（VH）药理学失活对大鼠巴甫洛夫恐惧条件反射的影响。僵住行为作为恐惧的衡量指标。在训练前向VH注射GABAA受体激动剂蝇蕈醇，会破坏听觉恐惧条件反射，但不影响情境恐惧条件反射；向DH注射则不影响恐惧条件反射。对VH或DH进行预测试失活不影响条件性僵住的表达。对VH进行训练前电解损伤可重现蝇蕈醇注射的效果，而训练后VH损伤则会破坏听觉和情境性僵住。因此，VH中的神经元在听觉恐惧条件反射的形成以及在某些条件下听觉和情境恐惧的表达中起着重要作用。
