Parsons Teresa Camille, Otto Tim
Program in Behavioral Neuroscience, Department of Psychology, Rutgers, The State University of New Jersey, New Brunswick, NJ 08903, USA.
Neurobiol Learn Mem. 2008 Jul;90(1):261-8. doi: 10.1016/j.nlm.2008.03.007. Epub 2008 May 16.
The current study examined the effects of temporary inactivation of the DH on freezing, rearing, ambulating, grooming, and whisking behavior in an explicitly nonspatial contextual fear conditioning paradigm in which olfactory stimuli served as temporally and spatially diffuse contexts. Prior either to training, testing, or both, male Sprague-Dawley rats received bilateral microinfusions of saline or the GABA(A) agonist muscimol into the DH. Results indicate that temporary inactivation of DH produced both anterograde and retrograde deficits in contextually conditioned freezing, while sparing the acquisition and expression of freezing to a discrete auditory or olfactory CS. These data suggest that there is a decidedly nonspatial component to the role of DH in contextual conditioning, and that olfactory contextual conditioning is a fruitful means of further exploring this function.
本研究在一个明确的非空间情境恐惧条件反射范式中，考察了背侧海马（DH）暂时失活对僵立、竖毛、走动、梳理和胡须抖动行为的影响，在该范式中嗅觉刺激作为时间和空间上弥散的情境。在训练、测试或两者之前，雄性斯普拉格-道利大鼠接受双侧微量注射生理盐水或GABA(A)激动剂蝇蕈醇至背侧海马。结果表明，背侧海马的暂时失活在情境条件化僵立中产生了顺行性和逆行性缺陷，同时不影响对离散听觉或嗅觉条件刺激的僵立习得和表达。这些数据表明，背侧海马在情境条件化中的作用存在一个明确的非空间成分，并且嗅觉情境条件化是进一步探索该功能的有效手段。
