Babiloni C, Vecchio F, Babiloni F, Brunelli G A, Carducci F, Cincotti F, Pizzella V, Romani G L, Tecchio F T, Rossini P M
Dipartimento di Fisiologia Umana e Farmacologia, Universita degli Studi di Roma La Sapienza, Rome, Italy.
Behav Neurosci. 2004 Feb;118(1):214-22. doi: 10.1037/0735-7044.118.1.214.
Previous neuroimaging evidence revealed an "invasion" of "hand" over "lower limb" primary sensorimotor cortex in paraplegic subjects, with the exception of a rare patient who received a surgical motor reinnervation of hip-thigh muscles by the ulnar nerve. Here, the authors show that a functional reorganization of cortico-muscular and cortico-cortical oscillatory coupling was related to the recovery of the rare patient, as a paradigmatic case of long-term plasticity in human sensorimotor cortex after motor reinnervation of paraplegic muscles. This conclusion was based on electroencephalographic and electromyographic data collected while the patient and normal control subjects performed isometric muscle contraction of the left hand or lower limb. Cortico-muscular and cortico-cortical coupling was estimated by electroencephalographic-electromyographic coherence and directed transfer function of a multivariate autoregressive model.
先前的神经影像学证据显示，截瘫患者的“手部”初级感觉运动皮层“侵入”了“下肢”区域，但有一位罕见的患者除外，该患者接受了尺神经对髋部-大腿肌肉的手术运动再支配。在此，作者表明，皮质-肌肉和皮质-皮质振荡耦合的功能重组与这位罕见患者的恢复有关，该患者是截瘫肌肉运动再支配后人脑感觉运动皮层长期可塑性的一个典型案例。这一结论基于患者和正常对照受试者在进行左手或下肢等长肌肉收缩时收集的脑电图和肌电图数据。皮质-肌肉和皮质-皮质耦合通过脑电图-肌电图相干性和多元自回归模型的定向传递函数进行估计。
