通过表皮生长因子受体的Wnt信号传导：在乳腺癌中起作用？
Wnt signalling via the epidermal growth factor receptor: a role in breast cancer?
作者信息
Musgrove Elizabeth A
机构信息
Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.
出版信息
Breast Cancer Res. 2004;6(2):65-8. doi: 10.1186/bcr737. Epub 2003 Oct 24.
Abstract
Recent data have suggested the epidermal-growth-factor receptor (EGFR) as a point of convergence for several different classes of receptor. Civenni and colleagues have now demonstrated crosstalk between Wnt signalling and the EGFR, showing that in breast epithelial cells Wnts activate downstream targets of the EGFR, including cyclin D1. Given the role of members of these pathways in the aetiology of breast cancer and as markers of outcome and potential therapeutic targets in breast cancer, this observation has a number of potential implications important for both the basic biology of breast cancer and the clinical management of the disease.
摘要
近期数据表明，表皮生长因子受体（EGFR）是几类不同受体的汇聚点。Civenni及其同事现已证明Wnt信号通路与EGFR之间存在相互作用，表明在乳腺上皮细胞中，Wnts可激活EGFR的下游靶点，包括细胞周期蛋白D1。鉴于这些信号通路的成员在乳腺癌病因学中的作用，以及作为乳腺癌预后标志物和潜在治疗靶点，这一观察结果对乳腺癌的基础生物学和疾病的临床管理都有许多潜在的重要意义。
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