Collins Catherine A, DiAntonio Aaron
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Neuron. 2004 Feb 19;41(4):489-91. doi: 10.1016/s0896-6273(04)00078-9.
The function and regulation of actin-cytoskeletal dynamics during synaptic growth is poorly understood. In this issue of Neuron, Coyle et al. report the identification of nervous wreck (nwk), a synapse-specific adaptor molecule in Drosophila that regulates synaptic growth and morphology via Wasp, a well-characterized mediator of actin dynamics.
肌动蛋白细胞骨架动力学在突触生长过程中的功能和调节机制目前还知之甚少。在本期《神经元》杂志中，科伊尔等人报告了对神经破坏因子（nwk）的鉴定，它是果蝇中一种突触特异性衔接分子，通过Wasp（一种已被充分表征的肌动蛋白动力学介质）调节突触生长和形态。
