Mysteries of the transferrin-transferrin receptor 1 interaction uncovered.
作者信息
Richardson D R
机构信息
Children's Cancer Institute Australia for Medical Research, The Iron Metabolism and Chelation Program, PO Box 81, High Street, Randwick, Sydney, New South Wales 2031, Australia.
出版信息
Cell. 2004 Feb 20;116(4):483-5. doi: 10.1016/s0092-8674(04)00165-5.
Abstract
How does the iron (Fe) binding protein, transferrin (Tf), bind to the transferrin receptor 1 (TfR1) to donate Fe to cells? In this issue of Cell, Cheng et al., describe the molecular structure of the human TfR1-Tf complex, This atomic model shows that Tf binds laterally to the TfR1 dimer and extends into the gap between the bottom of the receptor ectodomain and the membrane.
摘要
Zotero 插件