Grimm Erich L, Roy Bruno, Aspiotis Renee, Bayly Christopher I, Nicholson Donald W, Rasper Dita M, Renaud Johanne, Roy Sophie, Tam John, Tawa Paul, Vaillancourt John P, Xanthoudakis Steven, Zamboni Robert J
Merck Frosst Centre for Therapeutic Research, Merck Frosst Canada & Co. PO Box 1005, Pointe-Claire-Dorval, Québec, Canada H9R 4P8.
Bioorg Med Chem. 2004 Mar 1;12(5):845-51. doi: 10.1016/j.bmc.2004.01.007.
A robust method for the solid phase synthesis of a series of selective caspase-3 peptide inhibitors is described. The inhibitors can be obtained after cleavage from the solid support without further purification.